Welcome to the Microbial Spatial Gene regulation Lab
Mission of the lab
We investigate how the spatiotemporal control of gene expression influences microbial cell physiology and differentiation
We combine high-resolution imaging techniques, molecular biology and genetics to study gene regulation in single fungal and bacterial cells, to understand how single cells adopt both individual and collective strategies to optimize their fitness
We love microbes!
S. cerevisiae
Filamentous S. cerevisiae
Candida albicans
Arbuscular mycorrhizal fungi
Aspergiullus niger
E. coli
We are always open to explore the physiology of new microorganisms. Contact us for collaborations!
1 - Methods development for RNA visualization and imaging analysis in fixed microbial cells based on single molecule RNA FISH (smFISH)
smFISH-IF in S. cerevisiae
2 - Methods development for RNA imaging in live microbial cells based on the MS2 and PP7 systems
Live imaging MS2 tagged mRNAs Tutucci et al. 2022
3 - Regulation of filamentous fungi differentiation and biofilm formation
Candida albicans
4 - RNA localization and spatial control of protein synthesis
5 - Regulation of mRNA degradation in S. cerevisiae
6 - Development of imaging analysis pipelines for microbial species
Questions?
Contact evelina.tutucci[at]vu.nl to get more information on the projects
Support:
